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In selecting PD biomarkers for PK-PD strategies in early research phases, which of the following statements is true?
A. A PD marker ideally is several metabolic steps down from the drug's target of action. B. Robust animal models can remove the need to test early-phase PK-PD responses in humans. C. The PD output in animal models should ideally mimic the cell-based assay. D. PK and PD blood draws should not be performed on the same animals. E. There are insignificant inter-species differences in PK.
Sagot :
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