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Arsenate (AsO4 3-) closely resembles Pi in structure and reactivity. In the reaction catalyzed by Glyceraldehyde 3-phosphate dehydrogenase, arsenate can replace phosphate in attacking the energy-rich Thioester intermediate. The product of this reaction, 1-arseno-3-phosphoglycerate, is unstable. It and other acyl arsenates are rapidly and spontaneously hydrolyzed. What is the effect of arsenate on energy generation in a cell?
Sagot :
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