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In the biosynthesis of cholesterol: a. 3-hydroxy-3-methyl glutaryl CoA (HMG CoA) is synthesized by mitochondrial HMG CoA synthase. b. HMG CoA reductase catalyzes the rate-limiting step. c. The conversion of mevalonic acid to farnesyl pyrophosphate proceeds via the condensation of three molecules of mevalonic acid. d. The condensation of two farnesyl pyrophosphates to form squalene is a freely reversible reaction. e. The conversion of squalene to lanosterol is initiated by formation of the fused ring system, followed by addition of oxygen.
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