An older adult patient presents with a history of gradual onset of pain in her hands, particularly at the base of her thumbs and her knees, worsening over the past 2 years. She reports that her symptoms are most severe towards the end of the day and after prolonged activity. On examination, there is a bony enlargement of the affected joints and crepitus with the movement of the knees. Which of the following diagnostic findings would be most expected from them?

1 - Rheumatoid factor and anti-cyclic citrullinated peptide antibodies
2 - Elevated erythrocyte sedimentation rate and C-reactive protein
3 - Uric acid crystals and inflammatory cells in joint fluids
4 - Joint space narrowing and osteophyte formation on X-ray