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Why are chlordiazepoxide and diazepam preferred benzodiazepines for alcohol withdrawal management?
- They are long-acting, providing a self-tapering effect. - They are short-acting, reducing the risk of accumulation and overdose. - They enhance GABA activity more selectively than other benzodiazepines. - They are more potent at the GABA-A receptor than other benzodiazepines, making them effective at lower doses. - They have minimal effect on liver enzymes, making them safer for patients with liver impairment.
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