Answered

Expand your knowledge base with the help of IDNLearn.com's extensive answer archive. Get prompt and accurate answers to your questions from our community of experts who are always ready to help.

Phenylephrine is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCL). The conjugate acid (PEH+) of phenylphrine has a pKa = 5.5. At a physiological pH of 7.4. what is the ratio of concentrations, [PE]/[PEH+]?

Sagot :

Jufsanabriasaidn

Answer:

The ratio of concentrations is 79.4

Explanation:

Using Henderson-Hasselbalch equation we can solve the [PE]/[PEH+] ratio:

pH = pKa + log [A-] / [HA]

Where pH is 7.4

pKa of the phenylphrine is 5.5

[A-] is the weak base = [PE]

And [HA] is the conjugate acid [PEH+]

Replacing:

7.4 = 5.5 + log [PE] / [PEH+]

1.9 = log [PE] / [PEH+]

79.4 = [PE] / [PEH+]

The ratio of concentrations is 79.4

Thank you for using this platform to share and learn. Don't hesitate to keep asking and answering. We value every contribution you make. IDNLearn.com is your source for precise answers. Thank you for visiting, and we look forward to helping you again soon.