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well there's various actions in your life that will affect you.
For example if you decide to smoke or drink, it can lead to permanent damage to the body depending on how long you've done it and if you are planning to quit it as well. From smoking you could get several types of cancer, because of the toxins and chemicals that you inhale, and for drinking alcohol you the damage is slower, but it does affect your organs.
Another example is how you eat, again being over-weight can damage the body pretty badly, and can lead to heart problems as well. The same things happens with being under-weight.
Overall not taking care of your body can have everlasting effects on your life, and depending on how long you've done them and how you are trying to stop it, it can be pretty permanent.