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Answer: A karyotype is simply a picture of a person's chromosomes. In order to get this picture, the chromosomes are isolated, stained, and examined under the microscope. Most often, this is done using the chromosomes in the white blood cells. A picture of the chromosomes is taken through the microscope.
Karyotypes are prepared from mitotic cells that have been arrested in the metaphase or prometaphase portion of the cell cycle when chromosomes assume their most condensed conformations. A variety of tissue types can be used as a source of these cells.
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