The elimination rate constant (usually a first-order rate constant) represents the fraction of xenobiotics that is eliminated from the body during a given period of time.
For instance, when the value of the elimination rate constant of a xenobiotic is 0.25 per hour, this means that ∼25% of the amount remaining in the body is excreted each hour. The rate constant is calculated from the slope (−k/2.303) of the blood concentration and time curve (log–linear scale).
Translation: Summary of pharmacokinetic parameters of Glimepiride tablets after a single p.o. administration of 8 mg to 14 healthy volunteers.
