Answered

IDNLearn.com offers a user-friendly platform for finding and sharing knowledge. Get timely and accurate answers to your questions from our dedicated community of experts who are here to help you.

A woman and man have approached you for genetic counseling and are concerned about a hereditary form of deafness in their family. Both have normal hearing and there are no children. The woman's father has autosomal dominant sensory-neural deafness. Assume he is heterozygous. This hearing impairment displays onset at about age 10, and penetrance appears to be about 70%. There is no family history of deafness among the man's relatives. What is the probability that the woman is a carrier of the deafness allele

Sagot :

Answer:

35% is the probability that the woman is a carrier of the deafness allele

Explanation:

Both man and woman have normal hearing

Woman's father has autosomal dominant sensory-neural deafness - Dd

Genotype of heterozygous Woman's father = Dd

Let us assume that woman’s mother has normal hearing = dd

Dd * dd

Dd, Dd, dd, dd

Two deaf and two normal offspring.  

Since the penetration is of 70%, the probability of woman being a carrier is  

½ * 70% = 0.35

Thank you for contributing to our discussion. Don't forget to check back for new answers. Keep asking, answering, and sharing useful information. Thank you for visiting IDNLearn.com. We’re here to provide accurate and reliable answers, so visit us again soon.