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Sickle cell disease is a recessive trait which causes a deformation in red blood cells due to a mutation in the gene that codes for hemoglobin. Consider a father and a mother BOTH with the genotype Hh, where H is the normal hemoglobin gene, and h is the gene that codes for the defective hemoglobin. What percent of their children will have the genotype hh, which means they will have the full-blown disease?
Answer: Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels.
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