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Answer:
There's a lot.
Explanation:
Differences
The stage play makes a huge deal of Angelica's sacrifice to not be with Alexander. However Angelica is already married beforehand in real life, so she didn't really have a choice.
Washington's first choice for secretary was not Alexander. It was actually Robert Morris.
John Adams didn't fire Hamilton.
Similarities
Hamilton was an immigrant and orphan.
Hamilton was against Slavery.
First Treasury Secretary.