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What components of cells are most important for filtration?

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PeterPan58idn
ANSWER:
The fenestrated endothelial cell, the glomerular basement membrane (GBM), and the podocyte are the most important components of cell for filtration.

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The most important cells for filtration is

The filtration barrier consists of 3 components:

  • endothelial cells of glomerular capillaries.
  • Glomerular basement membrane.
  • Epithelial cells of Bowman's Capsule (podocytes)

Structure of Endothelial Cells

The glomerular capillary endothelium has many perforations called fenestrae, which are pores about 70nm in diameter. These pores actually do not restrict the movement of water and proteins or large molecules but instead prevent the filtration of blood cells (e.g. RBCs).

Surrounding the luminal surface of the endothelial cells is a glycocalyx consisting of negatively charged glycosaminoglycans. This functions to hinder the diffusion of negatively charged molecules by repelling them due to like charges.

Learn more about  cells

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