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When a friend shows signs of abusing alcohol or other drugs, it's hard to know what to do or say. If someone can recognize the symptoms of addiction, they may be able to help a friend or family member who struggles with this mental illness. Sometimes it's difficult to distinguish normal teenage moodiness or angst from signs of drug use. One of the hallmarks of substance abuse and addiction is that a person separates themselves from their family and friends and loses interest in hobbies or their favorite things. Bloodshot eyes and mood changes are just two of several signs that someone may be abusing drugs. Anyone who is addicted to heroin usually has constricted pupils.