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Part B: Which of the following can you conclude about the hemoglobin in individuals with sickle cell
anemia? Choose two answers that apply.


The amino acids sequenced for the abnormal hemoglobin replaced a Glucine (Glu) for a Leucine
(Leu).

The amino acids sequenced for the abnormal hemoglobin was the same as it was for the normal
hemoglobin.

There was an error in the transcription from DNA to RNA.

The amino acids sequenced for the abnormal hemoglobin replaced a Glucine (Glu) for a Valine
(Val).

There was an error in the nucleotide sequence in the original DNA strand.

Sagot :

Sandlee09idn

Sickle cell anemia is caused by a substitution mutation in the Beta Globin chain of chromosome 11.

Sickle cell anemia results from the point mutation that causes the codon previously responsible for coding for Glucine, to now code for the amino acid Valine. This occurs due to the substitution of an A nucleotide in codon six, for that for a T nucleotide.

The mutation in this codon occurs during the duplication of DNA and causes problems during the transcription process. This is when the code is read in order to produce the amino acids necessary to create proteins. Though the problem arises during transcription, the error was in the nucleotide sequence of the original DNA sequence due to its hereditary nature.

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