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What would happen if the cell membrane only had 1 layer of phospholipids?

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Answer:  

If phospholipid bilayer diffusion is normally negligible, there will be tissues (largely lacking in transporters that may be expressed elsewhere) which, despite the relative functional similarity of their phospholipids, are very poor at taking up drugs: the blood–brain [33], blood–testis [34], and blood–retina

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