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A single base substitution mutation is least likely to be deleterious when the base change results in _the third base in the mRNA codon_. That is called wobble.
A single base substitution mutation is least likely to be deleterious when the base change results in a codon that specifies the same amino acid as the original codon.
What is the effect of single base substitution mutation?
A substitution mutation can cause the following: Change in the coding of amino acids codon to a particular stop codon resulting in an incomplete protein, which is usually non-functional. Can cause Silent mutations where a codon change can encode the same amino acid resulting in no changes in the protein synthesized.
What is base substitution mutation?
Base substitutions are the simplest type of gene-level mutation, and they involve the swapping of one nucleotide for another during DNA replication. For example, during replication, a thymine nucleotide might be inserted in the place of a guanine nucleotide.
Learn more about mutation here: brainly.com/question/2570717
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