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Answer and Explanation: Settler colonies were areas outside Europe in which so many European immigrants voluntarily settled that their numbers were large enough to secure their political dominance, even if they were in a minority among the indigenous population. The impact disease caused was that it released microbes to which native inhabitants had no immunity caused sickness and death everywhere Europeans settled. Along the New England coast between 1616 and 1618, epidemics claimed the lives of 75 percent of the indigenous people. In the 1630s, half of the Huron and Iroquois people living near the Great Lakes died of smallpox.