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Negative neuroplasticity. Environmental factors that decrease cognitive reserve, inhibits neuronal connections and causes sparse neuronal connections. The result if that over time the brain becomes less efficient.A lot of the ways in which our brain function degrades that we typically think of as part of “just getting old” is really negative neuroplastic change. As people grow older, they unknowingly contribute to their brain's decline by not using and challenging it as much. For example, a person retires from work.Both positive neuroplasticity and negative neuroplasticity refer to the actual morphological and neurochemical changes that occur in the nervous system and brain between neurons in response to adapting to environmental demands or press (Figure 1; Vance & Crowe, 2006; Vance, Roberson, McGuiness, & Fazeli, 2010).