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In British Pharmacopoeia (BP) assay for content of active ingredient, 20 tablets
(each stated to contain 50 mg of active ingredient) of total weight 6.5142g were
powdered. A sample of the powdered tablets of weight 0.3460g was extracted
with 0.1M NaOH, the extract filtered, and the filtrate made up to 100 cm3 with
0.1 M NaOH. A dilution ( 1 in 100 ) with 0.1M NaOH gave an absorbency value
of 0.345 at 256 nm using 1 cm cells. Given that the A (1%, 1cm) is 658 at 257 nm
in 0.1M NaOH. Calculate the percentage of the stated amount of active
ingredient per tablet

Sagot :

Ajinemsidn

The percentage of the stated amount of active ingredient per tablet is = 15.35%

Calculation of percentage composition of active ingredient

Each tablet of the drug for assay contains= 50 mg of active ingredient.

The mass of the 20 tablets selected= 6.5142g

Therefore the mass of one tablet= X

Make X the subject of formula,

X = 6.5142/20

X= 0.32571g

Convert the 0.32571gram to miligram by multiplying by 1000 which is = 325.71mg

Therefore percentage of the stated amount of active ingredient per tablet is = 50/325.71 × 100/1

= 5000/325.71

= 15.35%

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