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The probability that their first child will have sickle cell disease is 0.25.
A man and a woman both are carriers of sickle cell anaemia.
The sickle cell anaemia genotype is ss whereas for producing normal haemoglobin, we have SS or Ss (Carrier).
When both man and woman are carriers, we have
Ss, Ss.
Thus, the probability that the couple would have a child that was also a carrier of sickle cell anemia is 0.25.
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