A mutant p53 gene can lead to the production of a , which in turn results in

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01-08-2022
Biology

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A mutant p53 gene can lead to the production of a , which in turn results in

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Aryanagarwal466idn Aryanagarwal466idn · Answer 1 · 2022-08-06T00:01:04-04:00

A "faulty transcription factor" produced by a mutated p53 gene, prevents the transcription or translation of a polypeptide that prevents cell proliferation.

Tumor suppressor,p53 gene:

The p53 gene, a tumor suppressor is frequently inactivated during the tumorigenic process. The p53 gene is often altered, producing a persistent mutated polypeptide whose development is thought to be a characteristic of cancer cells.
In contrast to losing their tumor-suppressing properties, mutant p53 proteins frequently acquire new carcinogenic properties that provide cancer cells an edge in terms of both survival and proliferation.
It is fascinating to note that p53 gene mutations have been linked to several stages of the multi-step malignant transformation process, each of which contributes differently to tumor start, amplification, competitiveness, and migration.

Learn more about the p53 gene here:

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