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UCP1 (uncoupling protein 1) in brown adipose tissue help to dissipate heat in hibernating mammals during winter.
The uncoupling protein, also known as thermogenin, is a 33 kDa inner-membrane mitochondrial protein that is found only in brown adipocytes in mammals. It serves as a proton transporter, allowing the proton gradient produced by the respiratory chain to be dissipated as heat and uncoupling oxidative phosphorylation in the process.
Uncoupling protein 1 (UCP1) is a membrane protein that is present in the mitochondrial inner membrane of brown adipose tissue and helps mammals produce heat without shuddering. By including an uncoupler (FCCP), you can reduce the proton motive force and raise the level of cellular respiration by causing a short circuit of protons on the inner mitochondrial membrane. Substrate oxidation is the primary indicator of oxygen consumption in this condition.
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