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A patient infected with a mutant strain of Bordetella pertussis that lacks functional adhesins will most likely not develop the disease.
Adhesins are any of the several factors that enable bacteria to adhere to epithelial surfaces of the host cell as a step towards infection.
It is very cogent for bacterial pathogens to attach or adhere to the surface of a host cell because they can be easily flushed off.
However, this means that if a bacterial pathogen cannot adhere successfully to a host cell surface, it will likely not be able to replicate and cause disease.
Therefore, a patient infected with a mutant strain of Bordetella pertussis that lacks functional adhesins will most likely not develop the disease.
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The most likely in a patient infected with B pertussis that lacks functional adhesins is that bacterium cannot colonize the lower respiratory system.
Adhesins are specific proteins used by cells (both host cells and pathogenic microorganisms) capable of binding to other cell surfaces.
These proteins (adhesins) are fundamental during the disease progression in order to infect suitable hosts, thereby they are virulence factors and therapeutic targets.
In conclusion, the most likely in a patient infected with B pertussis that lacks functional adhesins is that bacterium cannot colonize the lower respiratory system.
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