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Tetracycline is an antibiotic that works by binding to the 30s subunit of bacterial ribosomes, thus inhibiting protein synthesis. This drug is able to cross the cell membrane because as a weak base, it can cross the membrane in its uncharged form.
Tetracycline, an antibiotic, inhibits protein synthesis in what way?
- Tetracyclines prohibit aminoacyl-tRNA from joining the bacterial ribosome, hence inhibiting the production of bacterial proteins. Therefore, depending on whether the vulnerable organism is a gram positive or gram negative, these molecules must pass through one or more membrane systems in order to engage with their targets.
- Tetracyclines travel via the OmpF and OmpC porin channels of gram-negative enteric bacteria as positively charged cation-tetracycline coordination complexes, most likely magnesium.
- The Donnan potential draws the cationic metal ion-antibiotic complex across the outer membrane, causing it to accumulate in the periplasm.
- There, the metal ion-tetracycline complex is likely to dissociate to release uncharged tetracycline, a weakly lipophilic molecule that can diffuse through the lipid bilayer regions of the inner (cytoplasmic) membrane.
Learn more about the Tetracycline with the help of the given link:
https://brainly.com/question/28341793
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