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Mutations in gamete (or sex cells) would have no adverse health effect on an individual; however, the mutations could be passed on to offspring.
What is Mutation?
A mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA at a particular gene locus. It creates a permanent change in gene's DNA sequence. Genetic variations are essential for humans to evolve, which is the process of change over generations. Mutations is result of errors in DNA replication during cell division, exposure to mutagens or a viral infection.
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