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Fecal microbiota transplantation (FMT) is usually recommended for remedy of recurrent Clostridium difficile contamination (rCDI). We performed a single-center randomized trial to evaluate the effects of FMT with those of fidaxomicin and vancomycin.
All sixty four sufferers acquired their assigned remedy. The mixture of scientific resolution and negative consequences from the check for CD were observed in 17 sufferers given FMTv (seventy one%), 8 sufferers given fidaxomicin (33%), and three sufferers given vancomycin (19%; P = .009 for FMTv vs fidaxomicin; P = .001 for FMTv vs vancomycin; P = .31 for fidaxomicin vs vancomycin). clinical decision become found in 22 sufferers given FMTv (92%), 10 patients given fidaxomicin (42%), and 3 patients given vancomycin (19%; P = .0002; P < .0001; P = .thirteen). consequences did not fluctuate significantly between patients who received FMTv as their preliminary remedy and sufferers who acquired rescue FMTv. there was 1 extreme adverse occasion that might were associated with FMTv.
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fecal microbiota transplantation is superior to fidaxomicin for treatment of recurrent clostridium difficile infection. explain?
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