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Sagot :
Pyruvate will be increase since the thiamine deficiency would prevent the transformation of pyruvate to acetyl CoA due to the lack presence of the pyruvate dehydrogenase. thus the answer should be Pyruvate.
Pyruvic acid has a carboxylic acid and a ketone functional group, making it the most basic of the alpha-keto acids.
The conjugate base, pyruvate, is an intermediary in several metabolic pathways throughout the cell.
Pyruvic acid can be synthesized from glucose by glycolysis, converted back to carbohydrates (such as glucose) via gluconeogenesis, or transformed to fatty acids via an acetyl-CoA process.
It may also be used to synthesize the amino acid alanine and fermented into ethanol or lactic acid.
When oxygen is present, pyruvic acid supplies energy to cells via the citric acid cycle (also known as the Krebs cycle), and when oxygen is not present, it ferments to produce lactate.
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