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Osteoclasts are involved in bone resorption and contribute to bone remodeling in response to bone growth and changes in mechanical loads on the skeleton. Osteoclasts are also involved in the long-term maintenance of blood calcium homeostasis
Osteoclasts are large, multinucleated phagocytes located within or adjacent to depressions or depressions on the bone surface called resorption pits that are involved in degradation in a key process called bone resorption. Osteoclasts remove bone by dissolving minerals and breaking down matrix in a process called bone resorption. Osteoclasts are the derived from the same of the progenitor cells in the bone marrow that produce white blood cells. Osteoclasts are specialized multinucleated giant cells that resorb bone. This is primarily done by remodeling of the extracellular matrix. Osteoclasts are derived from monocyte fusion and have approximately 2-12 nuclei per cell.
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