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Endochondral Ossification takes place within membranes.
Endochondral ossification first takes place at the primary site at the center of the diaphysis, which allows formation of the two growth plates. Primary ossification center is the first area of a bone to start ossifying.
In long bones the primary centers occur in the diaphysis/shaft and in irregular bones the primary centers occur usually in the body of the bone. Endochondral ossification occurs in the bone tissue in the stage of early fetal development. It begins when MSCs start to produce a cartilage template of long bones, such as the femur and the tibia.
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