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Sagot :
Small blood vessels in the injured area enlarge, resulting in redness. Only peripheral bodily components, including the skin, sense heat as a result of increased blood flow through the area.
Histamine's significance in the immune response, best seen in inflammation (i.e., the local response of biological tissues to harm produced by physical damage, infection, or allergic reaction), depends critically on its influence on blood vessels. Mast cells in injured tissue release histamine, which causes the nearby blood vessels to widen and become more permeable. This enables fluid and immune system components, including blood plasma proteins and leukocytes (white blood cells), to leak from the bloodstream through the vessel walls and move to the site of tissue injury or infection, where they can start to fight the infection and hydrate and heal the injured tissues.
Does histamine release vasodilation?
Histamine can cause dilatation of submucosal arterioles through two different mechanisms: activation of sympathetic nerve terminal H3 receptors results in presynaptic suppression of vasoconstrictor tone and activation of vascular H1 receptors releases nitric oxide from the endothelium.
Does histamine cause vessel dilation?
Via activation of the H1 receptor, histamine increased vascular diameter and blood flow volume.
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