what was the effect on the amount of hoxd13 mrna when just segment c was deleted?

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05-12-2022
Biology

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what was the effect on the amount of hoxd13 mrna when just segment c was deleted?

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Jaiswaljyotiidn Jaiswaljyotiidn · Answer 1 · 2022-12-08T06:46:46-05:00

The quantity of Hoxd13 mRNA generated was unaffected by the ablation of segment C. Hoxd13 mRNA was only generated at a rate of around 60% of the control level.

The homeobox-containing gene HOXD13, which is situated at the most 5′ end of the HOXD cluster, is crucial for the development of the limbs. It has been established that human HOXD13 mutations can result in limb deformities, with varying degrees of expressivity and a broad range of clinical symptoms.

The first of multiple HOXD genes found in a group on chromosome 2 is HOXD13. Severe limb and genital deformities have been linked to deletions that eliminate the whole HOXD gene cluster or the 5' end of this cluster.

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