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Describe a mechanism by which a steroid hormone might act to increase intracellular levels of cyclic AMP. Match the words in the left column to the appropriate blanks in the sentences on the right. Reset Help activate decrease inhibit repressed induced increase Since steroid hormone-receptor complexes specific genes, a steroid hormone could in principle transcription of the gene for adenylate cyclase and, hence, steady-state level of this enzyme. Other possibilities could include the transcription of the synthesis of a phosphodiesterase inhibitor or synthesis of cAMP phosphodiesterase.

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The mechanism might involve suppressing the synthesis of cAMP phosphodiesterase or inducing the synthesis of a phosphodiesterase inhibitor.

The steady-state level of adenylate cyclase may rise as a result of steroid hormones activating transcription of the gene encoding this enzyme.

The placenta, the gonads, and the adrenal cortex all produce steroid hormones that are all produced from cholesterol and have a variety of clinically significant functions. The smooth endoplasmic reticulum and mitochondria are where steroid hormones are made.

Phosphodiesterase inhibitors are a class of drugs used to manage and treat conditions such as pulmonary arterial hypertension (PAH), erectile dysfunction (ED), benign prostatic hyperplasia (BPH), acute decompensated heart failure, psoriasis, psoriatic arthritis (PA), and atopic dermatitis.

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