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EGLN1 genes is associated with mutations that increase human adaption to high altitude.
Additionally, it was hypothesized in a prior study (4) that its PPARA genes locus was connected to Tibetans' ability to adapt to high altitudes and their level of HGB. The body creates extra red blood cells during acclimatization during a few days to weeks to make up for the reduced oxygen saturation of blood at high elevations. When the growth of red blood cells reaches its peak and then stops, full adaptation at high altitude has occurred. Additionally, because babies get less oxygen through their moms at elevations exceeding two miles, the likelihood of miscarriages is often greater there. After successfully adjusting to a high altitude, the body often has much more red blood cells and much more capacity for lung expansion than is necessary when returning to sea level.
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