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Nociceptors react to stimuli that could be harmful, such as noxious substances, temperature or pH extremes. In most cases, free nerve terminals of specialized neurons are connected to nociceptors.
The skin has three main types of nociceptors: polymodal nociceptors, which are uniquely linked to C fibers, A mechanosensitive nociceptors, and A chemo thermal nociceptors.
These various stimuli that affect mechanoreceptors (including proprioception), nociceptors, thermoreceptors, and chemoreceptors can all activate the somatosensory receptors.
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