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A ligand binding region will always exist on the lumen side of the ER whenever it is added during the production of the a transmembrane protein located in the plasma membrane.
Cytoplasm is the name for the gel-like substance which makes up a cell. In chemical processes, it acts as a catalyst. It provides a framework again for operation of other organelles within the cell. All of the procedures of cell division, growth, or replication take place in the cytoplasm of every cell.
Its cytoplasm, that also protects the components against damage, holds the components of the cell in place. It gives the cell its distinct shape and keeps the chemicals required for cellular function.
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