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An efficient chemical starting point for a drug development initiative can be a "fragment hit," a small molecule that has been shown to bind to a target protein.
An efficient chemical starting point for a drug development initiative can be a "fragment hit," a small molecule that has been shown to bind to a target protein. planning a strategy to grow the fragment into a powerful inhibitor or activator of the target after building up the method for hit recognition, figuring out the structures of the fragment-target complexes, creating an assay for assessing structure-activity relationships of the complex. Enhancing our knowledge of their binding qualities, which up to now has primarily been dependent on tacit knowledge and fragment complexes, could potentially increase our capacity to locate and advance fragment hits. We found a number of noteworthy characteristics, such as preferences for buried surface area, that these hits frequently share.
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