a group of immunologists are developing a human monoclonal antibody for the treatment of b-cell lymphoma. a requirement is that the antibody facilitate destruction of tumor cells by antibody-dependent cell-mediated cytotoxicity (adcc). for which of the following reasons are they not interested in igg2 antibodies?

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06-12-2022
Biology

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a group of immunologists are developing a human monoclonal antibody for the treatment of b-cell lymphoma. a requirement is that the antibody facilitate destruction of tumor cells by antibody-dependent cell-mediated cytotoxicity (adcc). for which of the following reasons are they not interested in igg2 antibodies?

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AyushiJain10idn AyushiJain10idn · Answer 1 · 2022-12-12T05:04:22-05:00

The reasons are they not interested in igG2 antibodies is because IgG2 does not bind efficiently to FcyRIIIA

What are antibodies?

The body defends itself against foreign toxins via proteins referred to as antibodies. a protein that plasma cells, a kind of white blood cell, generate in response to an antigen (a substance that causes the body to make a specific immune response). All that a single antibody can bind to is one specific antigen.

Because of their extremely poor binding to FcRIIIa, IgG2 allotypes do not stimulate NK cell-mediated ADCC activity. Since these subclasses bind with reduced affinity, IgG2 antibodies are favored when Fc-mediated effector actions are not required or desired.

Therefore the reasons are they not interested in igG2 antibodies is because IgG2 does not bind efficiently to FcyRIIIA

To know more about antibodies from the given link

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