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Chromosome translocations involving the Myc gene cause Burkitt lymphoma. A chromosome is disrupted during a chromosome translocation, allowing for association with pieces of other chromosomes.
Chromosome 8, which houses the Myc gene, is the site of the traditional chromosome translocation in Burkitt lymphoma. A very aggressive B cell neoplasm known as Burkitt lymphoma (BL) is distinguished by the translocation and dysregulation of the MYC gene on chromosome 8. Epstein-Barr virus has been related to sporadic Burkitt lymphoma (EBV). The virus that causes glandular fever is this one (mononucleosis).
Someone who has experienced mononucleosis may be more likely to develop NHL. But it's crucial to keep in mind that EBV is extremely widespread. A translocation of the MYC gene on chromosome 8 into one of the three immunoglobulin loci, which results in MYC protein overexpression and unchecked cell proliferation, is linked to all forms of Burkitt lymphoma. Recurrent chromosomal translocations are present in around 40% of B-cell lymphomas, and the majority of them are easily identifiable using either traditional (karyotyping) or molecular cytogenetics (fluorescent in situ hybridization, FISH).
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Correct Question:
Burkitt lymphoma is usually associated with what type of chromosome rearrangement?
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