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Prions infect organisms by entering brain cells and cause normal forms of the protein to refold into the prion form.
Since prions are only proteins without any genetic material, their manner of action is very different from those of bacteria and viruses. Correctly folded proteins are changed into the disease-associated form after a misfolded prion enters a healthy person, maybe through the consumption of infected food. The infectious prions that cause prion disease can arise in brain tissue when a large number of regular prion protein molecules alter their structure and group together. Therefore, a contagious, misshaped and aggregated prion protein is the cause of prions.
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