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Another method of causing RNA interference-mediated posttranscriptional gene silence for target genes is shRNA, also known as short hairpin or small hairpin RNA.
The shRNA is made up of an RNA molecule with a shape resembling a hairpin; it is somewhat larger than siRNA molecules and, in contrast to siRNA, is created inside the cell, in the nucleus. From a therapeutic standpoint, shRNA can be applied to the treatment of several illnesses, including cancer.
Several shRNA delivery strategies have been tested. A folate-targeted nanoparticle complexed with AR-shRNA improved radiosensitivity in prostate cancer. Additionally, WT-shRNA was given to melanoma cells via a transferrin-targeted PEG liposome.
As a result, shRNA, also known as short hairpin or small hairpin RNA, is a different way to cause RNA interference-mediated posttranscriptional gene silence for target genes. The shRNA is made up of an RNA molecule with a shape resembling a hairpin; it is somewhat larger than siRNA molecules and, in contrast to siRNA, is created inside the cell, in the nucleus.
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