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The encounter between indigenous Americans and Spanish explorers in the 15th century brought about significant impacts on both groups, including the spread of diseases and an exchange of crops and ideas.
When the indigenous Americans encountered the Spanish in the 15th century, it marked a significant period of exploration and conquest in the New World. The arrival of the Spanish led to an exchange of crops, diseases, people, and ideas, but also brought devastating epidemics like smallpox and measles that decimated the local Native American populations.
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