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Final answer:
Malaria was a significant issue during the building of the Panama Canal, tackled successfully by the U.S. and Cuban researchers.
Explanation:
Malaria was one of the biggest challenges faced during the construction of the Panama Canal. The U.S. medical service, along with Cuban researchers, discovered the link between mosquitoes and malaria, implementing measures to control its spread during the canal's construction.
Learn more about Panama Canal construction and disease control here:
https://brainly.com/question/38764782
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