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The rough endoplasmic reticulum is located in the cell's cytoplasm and is covered with ribosomes, while the nucleolus in the nucleus is where ribosomal RNA is assembled.
Rough endoplasmic reticulum (RER) is located in the cell's cytoplasm and is covered with ribosomes, giving it a rough appearance. The RER is responsible for synthesizing proteins that are destined for export or insertion into cell organelles or the cell membrane.
The nucleolus, found inside the nucleus, is the site where ribosomal RNA is aggregated with proteins to assemble ribosomal subunits for transport to the cytoplasm.
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