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The leading strand is synthesized continuously, while the lagging strand is synthesized in short fragments known as Okazaki fragments with the need for multiple primers.
The leading strand is synthesized continuously from a single primer by DNA polymerase, while the lagging strand is synthesized discontinuously in short fragments called Okazaki fragments, each requiring its own primer. The RNA primers are removed and replaced with DNA nucleotides, and DNA ligase seals the gaps between these fragments.
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