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Prior to administering an opioid, patients should be informed that the drug will:

A. increase neurotransmission, as these drugs prevent presynaptic [tex]Ca^{2+}[/tex] influx.
B. increase neurotransmission, as these drugs enhance presynaptic [tex]Ca^{2+}[/tex] influx.
C. decrease neurotransmission, as these drugs enhance presynaptic [tex]Ca^{2+}[/tex] influx.
D. decrease neurotransmission, as these drugs prevent presynaptic [tex]Ca^{2+}[/tex] influx.


Sagot :

Final answer:

Opioids decrease neurotransmission by preventing presynaptic Ca2+ influx.


Explanation:

Prior to administering an opioid, patients should be informed that the drug will:

  • Decrease neurotransmission, as these drugs prevent presynaptic Ca2+ influx.

When opioids interact with GABAergic neurons, they cause hyperpolarization and suppress the release of GABA onto dopaminergic VTA neurons, ultimately disinhibiting VTA neurons and increasing dopamine release onto downstream targets.


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