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Simple diffusion involves small and nonpolar molecules, while facilitated diffusion assists large and polar molecules using transport proteins in the membrane.
Simple diffusion is the movement of small and nonpolar molecules across a cell membrane without the need for assistance. On the other hand, facilitated diffusion involves the movement of large and polar molecules with the help of transport proteins in the membrane, such as channel proteins or carrier proteins.
Examples of substances moved via facilitated diffusion include polar molecules like glucose or amino acids. This process allows large or hydrophilic molecules and charged ions to enter and leave the cell.
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