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Ignaz Semmelweis and Joseph Lister advocated handwashing to prevent disease transmission.
Ignaz Semmelweis, a physician, suggested that hand washing would reduce the transmission of disease between patients.
His proposal was based on observing reduced mortality rates when physicians washed their hands with chlorinated lime water, showcasing the effectiveness of good hand hygiene in preventing infections.
Joseph Lister, another physician, also emphasized handwashing and cleanliness to reduce postsurgical infections, contributing to the acceptance of the germ theory of disease.
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