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Whole blood refers to a blood sample with an anticoagulant that has not been centrifuged; plasma contains clotting elements, while serum lacks these factors.
Whole blood is the term used to describe a blood sample that contains an anticoagulant additive and has not been spun in a centrifuge. When blood is centrifuged, plasma, the fluid portion of blood that still contains clotting elements, is separated from the blood cells. In contrast, serum is the fluid portion of blood left after coagulation has occurred, and clotting factors are largely depleted.
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