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Final answer:
In a 45-year-old patient with depression and a history of seizures, Bupropion (Wellbutrin) should be used with caution due to an increased risk of seizures at high doses.
Explanation:
Bupropion (Wellbutrin) should be used with caution in a 45-year-old patient with depression and a history of seizures due to an increased risk of seizures, especially at high doses. Bupropion is known to lower the seizure threshold, making it a risky choice for patients with a history of seizures.
Mirtazapine (Remeron), amitriptyline (Elavil), Paroxetine (Paxil), and Duloxetine (Cymbalta) are other antidepressants that may be considered as safer alternatives for patients with a history of seizures.
Learn more about Antidepressants and Seizure Risk here:
https://brainly.com/question/37485941
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